Anaphylaxis: Anaphylaxis is noted with codeine, among the substances in promethazine HCl and codeine phosphate oral Resolution.
Though critical, lifestyle-threatening, or lethal respiratory despair can occur Anytime for the duration of using promethazine HCl and codeine phosphate oral Option, the danger is biggest through the initiation of therapy, when promethazine HCl and codeine phosphate oral Resolution is employed concomitantly with other medicine that will result in respiratory despair [see Warnings and Safety measures (five.
g., Individuals with proof of improved intracranial force or brain tumors), promethazine HCl and codeine phosphate oral Alternative might decrease respiratory push, as well as the resultant CO2 retention can more improve intracranial force. Moreover, opioids produce adverse reactions which will obscure the clinical system of clients with head accidents.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and slightly soluble in Alcoholic beverages. The molecular excess weight is 406.37. Its molecular formulation is C18H21NO3•H3PO4 • ½ H2O, and it's got the subsequent chemical construction.
Pregnancy Checks: Diagnostic pregnancy checks dependant on immunological reactions among HCG and anti-HCG may well bring about false-detrimental or false-constructive interpretations.
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Make certain precision when prescribing, dispensing, and administering promethazine HCl and codeine phosphate oral Alternative. Dosing errors may end up in accidental overdose and Demise.
Promethazine Symptoms and signs or symptoms of overdosage with promethazine range between delicate depression of your central nervous program and cardiovascular procedure to profound hypotension, respiratory melancholy, unconsciousness and unexpected Loss of life.
Unresponsive Cough The dosage of promethazine HCl and codeine phosphate oral Alternative really should not be elevated if cough fails to respond; an unresponsive cough ought to be reevaluated in 5 days or sooner for achievable underlying pathology, like overseas system or lower respiratory tract disease [see Dosage and Administration (two.3)].
5.21 Drug/Laboratory Examination Interactions Due to the fact opioid agonists may well boost biliary tract strain, with resultant rise in plasma amylase or lipase ranges, perseverance of such enzyme levels may very well be unreliable for 24 hrs right after administration of a dose of promethazine HCl and codeine phosphate oral Alternative.
Tell clients that a household teaspoon just isn't an precise measuring machine and this kind of use could lead to overdosage and critical adverse reactions [see Overdosage (ten)]. For prescriptions wherever a measuring machine is just not read more delivered, a pharmacist can offer an proper calibrated measuring system and can provide Directions for measuring the correct dose.
Labor or Shipping Opioids cross the placenta and could create respiratory melancholy and psycho-physiologic effects in neonates. An opioid antagonist, for example naloxone, must be readily available for reversal of opioid-induced respiratory melancholy from the neonate. Opioids, including promethazine HCl and codeine phosphate oral Answer, can extend labor by steps which temporarily reduce the strength, duration, and frequency of uterine contractions.
Avoid using promethazine HCl and codeine phosphate oral Answer in adolescents 12 to 18 a long time of age who have other possibility aspects which could enhance their sensitivity on the respiratory depressant outcomes of codeine Except if the benefits outweigh the risks.
Make sure that patients have an oral dosing dispenser that measures the right volume in milliliters. Counsel people regarding how to use an oral dosing dispenser and properly measure the oral suspension as prescribed.